Saturday 25 April 2009
08:00 - 20:00 Registration
17:30 -19:30 Opening Ceremony
Anadolu Auditorium
17:30 - 19:30 Geoffrey Harris Prize Lecture
Chair: E. Nieschlag (Germany)
 Anadolu Auditorium
17:30 - 19:30 European Journal of Endocrinology Prize Lecture
Chair: C. Strasburger - Editor-in-Chief of EJE (Germany)
 Anadolu Auditorium
19:30 - 22:00 Welcome Reception

Sunday 26 April 2009
08:00-20:00 Registration
08:30 - 10:00 Symposium 1: PCOS
Chairs: : D. Micic (Serbia) & F. Kelestimur (Turkey)

 Halic Room
08:30 S1.1 Obesity, type 2 diabetes and PCOS – a common origin?
B. Yildiz (Turkey)
08:50 S1.2 Targeting insulin sensitivity in the treatment of PCOS
R. Pasquali (Italy)
09:10 S1.3 The Role of HPA Axis in Metabolic Derangements in PCOS
D. Macut (Serbia)
09:30 S1.4 Treatment of Infertility in Women with PCOS
K. Unluhizarci (Turkey)
08:30 - 10:00 Symposium 2: Beta Cell Proliferation, Survival and Secretion
Chairs: B. Glaser (Israel) & H. Ilkova (Turkey)

 Topkapi Rooms A+B
08:30 S2.1 Cell-cell communication and the regulation of insulin secretion
P. Jones (UK)
08:50 S2.2 Inflammation, Cytokines and Diabetes
C. M. Larsen (Denmark)
09:10 S2.3 Endoplasma reticulum stress and beta-cell apoptosis
D. Eizirik (Belgium)
09:30 S2.4 Incretin receptor signalling, b-cell proliferation and survival
D. Drucker (Canada)
08:30 - 10:00 Symposium 3: Genetics in Neuroendocrinology
Chairs: M. Tena-Sempere (Spain) & N. Ozbey (Turkey)

 Marmara Room
08:30 S3.1 Familial Hypopituitarism
P. E. Mullis (Switzerland)
08:50 S3.2 ACTH insensitivity syndromes
A. Clark (UK)
09:10 S3.3 The GPR54 Gene Mutations as a Cause for Hypogonadotropic Hypogonadism
A. Latronico (Brasil)
09:30 S3.4 Reversible Hypogonadotropic Hypogonadism
N. Pitteloud (USA)
10:00 - 10:15 Coffee Break & Exhibition
10:15-10:30 Presidential Address
Anadolu Auditorium
10:30-11:15 Plenary Lecture 1
Chair: J. Gromoll (Germany)
 Anadolu Auditorium
PL1 Early Influences on Epigenetic Regulation: Relevance to Chronic Disease
R. Waterland (USA)
11:15 - 12:45 Symposium 4: Gonadal Steroid Replacement
Chairs: G. Forti (Italy) & H. Azizlerli (Turkey)

 Anadolu Auditorium
11:15 S4.1 Testosterone and the Metabolic Syndrome
S. Arver (Sweden)
11:35 S4.2 Pharmacogenetics of Androgen Action
D. Canale (Italy)
11:55 S4.3 Androgen replacement in women
W. Arlt (UK)
12:15 S4.4 Diagnosis and Treatment of Estrogen Deficiency in Men
C. Carani (Italy)
11:15 - 12:45 Symposium 5: IGF 1 Survival, Proliferation and Cancer
Chairs: I. Robinson (UK) & U. Ozbek (Turkey)

 Halic Room
11:15 S5.1 IGF1, proliferation and cancer.
H. Werner (Israel)
11:35 S5.2 IGF, Somatotropic Plasticity and Mammalian Lifespan
M. Holzenberger (France)
11:55 S5.3 Nutrition, Physical Activity and Cancer Risks: The Role of Insulin and Insulin-like Growth Factor-I
R. Kaaks (Germany)
12:15 S5.4 IGF-I and neuroprotection
I. Torres-Aleman (Spain)
11:15 - 12:45 Symposium 6: Epigenetics and Endocrine Programming
Chairs: M. Dallman (USA) & P. Kadioglu (Turkey)

 Topkapi Rooms A+B
11:15 S6.1 Glucocorticoids and Developmental Programming
J. Seckl (UK)
11:35 S6.2 Nutritional Environment and the Development of Adipose Tissue
C. McMillen (Australia)
11:55 S6.3 Programming of the Stress System by the Maternal Care in Animal Models
S. Morley-Fletcher (France)
12:15 S6.4 Epigenetic programming and chronic physical aggression
R. Tremblay (Ireland - Canada)
11:15 - 12:45 Oral Communication 1: Endocrine Tumours
Chairs: A.J. van der Lely (The Netherlands) & A. Milewicz (Poland)

 Marmara Room
11:15 OC1.1 Optimizing time of Prophylactic surgery in RET Gene Carriers on the basis of Serum Calcitonin
Presenter: R. Elisei (Italy)
 Rossella Elisei; Cristina Romei; Valeria Bottici; Barbara Cosci; Guilia Renzini; Eleonora Molinaro; Laura Agate; Aldo Pinchera;
11:30 OC1.2 Long-term outcome of laparoscopic versus open adrenalectomy for adrenocortical carcinoma
Presenter: M. Fassnacht (Germany)
 Martin Fassnacht; David Brix; Wiebke Fenske; Peter Langer; Christoph Nies; Ayman Agha; Felix Beuschlein; Sarah Johanssen; Hubertus Riedmiller; Bruno Allolio;
11:45 OC1.3 131I-Iodometomidate radiotherapy for metastatic adrenocortical carcinoma – first clinical experience
Presenter: S. Hahner (Germany)
 Stefanie Hahner; Michael Kreissl; Martin Fassnacht; Sarah Johanssen; Heribert Haenscheid; Christoph Reiners; Bruno Allolio; Andreas Schirbel;
12:00 OC1.4 MicroRNA expression profiling and target prediction in adrenocortical tumors
Presenter: Zsofia Tombol (Hungary)
 Zsofia Tombol; Peter M. Szabo; Viktor Molnar; Zoltan Wiener; Janos Horanyi; Peter Riesz; Istvan Liko; Attila Patocs; Rolf-Christian Gaillard; Andras Falus; Karoly Racz; Peter Igaz;
12:15 OC1.5 Bone Morphogenetic Protein 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis
Presenter: Inga Johnsen (Germany)
 Inga Johnsen; Roland Kappler; Christoph Auernhammer; Felix Beuschlein;
12:30 OC1.6 Implication of the WNT/Β-CATENIN Signalling Pathway Activation in the Adenoma and in the Malignant Adrenocortical Cancer
Presenter: Barbara Czarnocka (Poland)
 Barbara Czarnocka; Anna Kasperlik-Zaluska; Krzysztof Bardadin; Katarzyna Roszkowska; Andrzej Cichocki;
13:00-14:30 Satellite Symposium: Novartis Evolving role of somatostatin analogues in the management of pituitary diseases
Topkapi Rooms A+B
13:00 Introduction from the Chairman
S. Lamberts (The Netherlands)
13:05 Clinical presentation and prognostic factors in pituitary tumours
M. Reincke (Germany)
13:25 New insights in somatostatin receptor signalling in pituitary tumour cells
M. Theodoropoulou (Germany)
13:45 The translation of new insights of somatostatin analogues into the clinical management of pituitary adenomas
A.Colao (Italy)
14:05 Q & A Session
Led by S. Lamberts, joined by all faculty members
14:25 Summary and Programme Close
S. Lamberts (The Netherlands)
13:00 - 14:30 Satellite Symposium: Amgen - Optimal Management of Primary Hyperparathyroidism: What is the latest evidence?
Chairs: M. Peacock (USA) & R. Bouillon (Belgium)

 Halic Room
Development of an asymptomatic disease: mechanisms and consequences of primary HPT
P. Schwarz (Denmark)
Diagnosis and management of primary HPT: What do the recent guidelines tell us?
R. Bouillon (Belgium)
The role of calcimimetics in the treatment of primary HPT
M. Peacock (USA)
13:00 -14:30 Lunch & Exhibition
The President meets Presidents of National and Affiliated Societies
 Marmara Room
13:00-15:30 Poster Session: Talk to me!
Posters Presented P1 - P220
14:30-15:30 HOT TOPICS
Chairs: P. Kelly (France) & N. Pitteloud (USA)

 Dolmabahce Rooms A+B+C
14:30 Prolactin receptor gene variants and human breast tumors
P. Touraine (France)
14:45 Complete and Quantitatively Normal Spermatogenesis in Familiall Hypogonadism with Mutation of the Beta Subunit of Luteinizing Hormone
M. Misrahi (France)
15:00 Thyroid Hormone Modulates Glucose Production via a Sympathetic Pathway from the Hypothalamic Paraventricular Nucleus to the Liver
A. Kalsbeek (The Netherlands)
15:15 Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a
F. Casanueva (Spain)
14:30 - 15:30 Meet the Expert 1
Loft Room
ME1 How to optimize the management of thyroid associated orbitopathy
P. Perros (UK)
14:30 - 15:30 Meet the Expert 2
Halic Room
ME2 Laproscopic and Cortical Sparing Surgery in Adrenal Tumors
M. Walz (Germany)
14:30 - 15:30 Meet the Expert 3
Topkapi Rooms A+B
ME3 Adolescent and adulthood gynecomastia
K. Kula (Poland)
14:30 - 15:30 Meet the Expert 4
Marmara Room
ME4 Treatment of osteoporosis
J. Payer (Slovakia)
15:30 - 17:00 Symposium 7: Glucocorticoid Action in the Brain
Chairs: J. Seckl (UK) & S. Gundogdu (Turkey)

 Halic Room
15:30 S7.1 Glucocorticoid Control of Chromatin Remodelling in Stress-related Learning and Memory
J. M.H.M. Reul (UK)
15:50 S7.2 Identification of a novel stress-regulated factor in the mouse brain that influences neuronal function and depressive-like behaviour
T. Rein (Germany)
16:10 S7.3 Genomic versus nongenomic corticosteroid effects
M. Joels (The Netherlands)
16:30 S7.4 Acute and chronic stress: Central and peripheral actions of glucocorticoids and insulin
M. Dallman (USA)
15:30 - 17:00 Symposium 8: Pituitary Cell Biology
Chairs: P. Kelly (France) & C. Alvarez (Spain)

 Topkapi Rooms A+B
15:30 S8.1 Imaging Pituitary cell networks and function
P. Mollard (France)
15:50 S8.2 New regulatory mechanisms controlling pituitary hormone secretion.
F. Gracia-Navarro (Spain)
16:10 S8.3 New regulators of pituitary cell proliferation
M. Korbonits (UK)
16:30 S8.4 Dual Function of Dopamine/Somatostatin Hybrid Agonists
A. Saveanu (France)
15:30 - 17:00 Symposium 9: Addison's Disease from genetics to Clinical Outcome
Chairs: K. Lovas (Norway) & S. Akalin (Turkey)

 Anadolu Auditorium
15:30 S9.1 Addison’s disease – natural history and long-term outcome
B. Allolio (Germany)
15:50 S9.2 Genetics of Autoimmune Addison’s Disease
S. Pearce (UK)
16:10 S9.3 Early Subclinical Addison's Disease
A. Falorni (Italy)
16:30 S9.4 New ways of delivering glucocorticoids
R. Ross (UK)
15:30 - 17:00 Oral Communication 2: Diabetes and Obesity
Chair: A. Grossman (UK) U. Pagotto (Italy)
 Marmara Room
15:30 OC2.1 A novel gene therapy strategy involving immune-modulation relinquished lymphocyte infiltration into islet grafted sites in STZ-induced diabetic rats
Presenter: E. Dirice (Turkey)
 Ercument Dirice; Ahter Dilsad Sanlioglu; Sevim Kahraman; Abdulkadir Omer; Mustafa Kemal Balci; Thomas S Griffith; Salih Sanlioglu;
15:45 OC2.2 Thymocyte migration is impaired in NOD mice: combined role of extracellular matrix and chemokines
Presenter: D. Mendes-da-Cruz (France)
 Daniella Mendes-da-Cruz; Moisés Bauer; Salete Smaniotto; Alexandre Keller; Mireille Dardenne; Wilson Savino;
16:00 OC2.3 Central ghrelin administration reduces starvation-induced inflammation in rats
Presenter: D. Stevanovic (Serbia)
 Darko Stevanovic; Vladimir Trajkovic; Dejan Nesic; Dragan Micic; Mirjana Sumarac-Dumanovic; Vera Popovic; Vesna Starcevic;
16:15 OC2.4 Mc2 receptor in adipocytes is significant for lipid composition and regular lipolysis
Presenter: N. Hatiboglu (Germany)
 Nilay Hatiboglu; Matthias J. Betz; Dirk Hadaschick; Brigitte Mauracher; Monika Rachl; Johann Demmelmair; Berthold Koletzko; Marc Slawik; Felix Beuschlein;
16:30 OC2.5 Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice
Presenter: S. Ghosh (Canada)
 Sanjoy Ghosh; Bruce Verchere; Ismail Laher;
17:00 - 17:15 Coffee Break & Exhibition
17:15 - 18:00 Plenary Lecture 2
Chair: R. Bouillon (Belgium)
 Anadolu Auditorium
PL2 Current and novel treatment targets for bone diseases
S. Papapoulos (The Netherlands)
18:00 - 19:30 Satellite Symposium: Pfizer - Expanding Experience with Somavert in Treatment of Acromegaly: Lessons from 5 years of ACROSTUDY
Chair: E. Ghigo (Italy)
 Halic Room
18:00 ACROSTUDY - An Update
A.J. van der Lely (The Netherlands)
18:15 Controlled Acromegaly - What Does It Mean?
P. Chanson (France)
18:30 Monitoring the Pituitary Tumour - What Have We Learned?
M. Buchfelder (Germany)
18:45 General Discussion
E. Ghigo, A.J. van der Lely, P. Chandon, M. Buchfelder
19:00 19:30 Reception Celebrating 5 Years of ACROSTUDY
18:00 - 19:30 Satellite Symposium: Ipsen - NET: The Interface between Endocrinology & Oncology
Chairs: W.W. de Herder (The Netherlands) & K. Oberg (Sweden)
Topkapi Rooms A+B
18:00 Introduction
W.W. de Herder (The Netherlands)
18:05

Molecular Pathogenesis of Neuroendocrine Tumours
D. Chung (USA)
18:25

CT and MRI in the Evaluation of Neuroendocrine Tumours
R. Reznek (UK)
18:45 Non Functioning Neuroendocrine Tumours
D. O�Toole (Ireland)
19:05 Emerging Molecular Therapeutic Approaches for the Management of Neuroendocrine Tumours
J. Yao (USA)
19:25 Take Home Messages
K. Oberg (Sweden)

Monday 27 April 2009
08:00-20:00 Registration
08:30 - 10:00 Symposium 10 - Secondary Osteoporosis
Chairs: S. Papapoulos (The Netherlands) & T. Sozen (Turkey)

 Anadolu Auditorium
08:30 S10.1 Growth hormone deficiency: bone matters
G. Gotherstrom (Sweden)
08:50 S10.2 Glucocorticoid effects on bone
H. Dobnig (Austria)
09:10 S10.3 Defining the target level for Vitamin D
G. E-H. Fuleihan (Lebanon)
09:30 S10.4 Sex Steroids in the Regulation of Bone Metabolism in Men
C. Ohlsson (Sweden)
08:30 - 10:00 Symposium 11 - New approaches to epigenetics and hormone/gene regulation
Chairs: J. Gromoll (Germany) & G.S. Direskeneli (Turkey)

 Halic Room
08:30 S11.1 Epigenetics in Stem Cells Identity
H. Jorgensen (UK)
09:00 S11.2 Existence of a “Dormant” Androgen Receptor-regulated Gene Program Revealed by ChIP-seq and its Influence in Prostate Cancer Progression
I. Garcia-Bassets (USA)
09:30 S11.3 MicroRNA and Glucocorticoid Signaling.
E. Vreugdenhil (The Netherlands)
08:30 - 10:00 Symposium 12 - Growth factors and signaling networks in pituitary tumours
Chairs: M. Korbonits (UK) & A. Spada (Italy)

 Topkapi Rooms A+B
08:30 S12.1 New mechanisms involved in pathogenesis of prolactinomas – critical role of the HMGA genes
M. Fedele (Italy)
08:50 S12.2 MAPK and PI3K/AKT Pathways in Pituitary Tumorigenesis
M. Cakir (Turkey)
09:10 S12.3 Molecular and histological prognostic markers in pituitary tumors
J. Trouillas (France)
09:30 S12.4 Predictive Markers of Pituitary Adenoma Behaviour
G. Kontogeorgos (Greece)
08:30 - 10:00 Oral Communication 3: Reproduction/Stress/Endocrine Disruptors
Chairs: R. Gaillard (Switzerland) & E. Malecka-Tendera (Poland)

 Marmara Room
08:30 OC3.1 Gabapentin for the treatment of hot flushes in women with natural or tamoxifen-induced menopause: a systematic review and a meta-analysis.
Presenter: K. Toulis (Greece)
 Konstantinos Toulis; Thrasivoulos Tzellos; Dimitrios Kouvelas; Dimitrios Goulis; Basil Tarlatzis; Ioannis Papadimas;
08:45 OC3.2 Variants in the ACVR1 gene are associated with AMH levels in women with Polycystic Ovary Syndrome.
Presenter: M. E. Kevenaar (The Netherlands)
 Marlies E. Kevenaar; Axel P.N. Themmen; Anke J. van Kerkwijk; Olivier Valkenburg; André G. Uitterlinden; Frank H. de Jong; Joop S.E. Laven; Jenny A. Visser;
09:00 OC3.3 Variable phenotype of PROKR2 and PROK2 mutations in central hypogonadism
Presenter: M. Bonomi (Italy)
 Marco Bonomi; Domenico Libri; Francesco Antonica; Marta Busnelli; Paolo Beck-Peccoz; Roberto Maggi; Csilla Krausz; Luca Persani;
09:15 OC3.4 Reference Ranges for Sex Hormone-Binding Globulin and Free Testosterone Index in Adult Men.
Presenter: N. Friedrich (Germany)
 Nele Friedrich; Henry Volzke; Alexander Krebs; Matthias Nauck; Henri Wallaschofski;
09:30 OC3.5 The xenoestrogen bisphenol A inhibits postembryonic vertebrate development by antagonizing gene regulation by thyroid hormone
Presenter: Y-B. Shi (USA)
 Yun-Bo Shi; ;
09:45 OC3.6 Cortisol as a prognostic marker of outcome in acute ischemic cerebrovascular events
Presenter: S. Neidert (Switzerland)
 Stefanie Neidert; Mira Katan; Felix Fluri; Nils Morgenthaler; Philipp Schuetz; Beat Mueller; Mirjam Christ-Crain;
10:05 - 10:50 Plenary Lecture 3
Chair: R. De Kloet (The Netherlands)
 Anadolu Auditorium
PL3 Stress and the brain: from adaptation to disease
F. Holsboer (Germany)
10:50 - 11:15 Coffee Break & Exhibition
11:15 - 12:45 Symposium 13: Surgery for 'Asymptomatic Hyperparathyroidism' (Pro-Con)
Chair: P. Selby, UK
 Anadolu Auditorium
S13.1 PRO: Surgery for Asymptomatic Primary Hyperparathyroidism
J.Nordenstrom (Sweden)
S13.2 CON: Management of Mild Primary Hyperparathyroidism
J. Bollerslev (Norway)
11:15 - 12:45 Symposium 14: Thyroid
Chairs: J. Koehrle (Germany) & T. Ozcelik (Turkey)

 Halic Room
11:15 S14.1 TSH receptor and Thyroid Diseases
S. Costagliola (Belgium)
11:35 S14.2 DUOX2 gene and thyroid disease
J. Moreno (The Netherlands)
11:55 S14.3 Molecular basis of Non Thyroidal Illness Syndrome
J. Lado-Abeal (Spain)
12:15 S14.4 Type 3 deiodinase and cancer
D. Salvatore (Italy)
11:15 - 12:45 Symposium 15: Progress in understanding and management of diabetes
Chairs: J. Christiansen (Denmark) & I. Satman (Turkey)

 Topkapi Rooms A+B
11:15 S15.1 The metabolic syndrome is getting nervous
J.A. Romijn (The Netherlands)
11:35 S15.2 The Metabolic Memory
A. Ceriello (UK)
11:55 S15.3 Role of the Fatty Liver (NAFLD) in the Pathogenesis and Treatment of Type 2 Diabetes
H. Yki-Jarvinen (Finland)
12:15 S15.4 Insulin Analogues in Type 2 Diabetes - How Far Have We Come?
A. Vaag (Denmark)
11:15 - 12:45 Highlight Session 1: Basic
Chairs: L. Persani (Italy) & J. Castano (Spain)

 Marmara Room
11:15 HTB1 Characterization of a mouse model with mutagenesis induced hyperaldosteronism
Presenter: A. Spyroglou (Germany)
 Ariadni Spyroglou; Sibylle Wagner; Jenny Manolopoulou; Constanze Hantel; Martin Reincke; Martin Bidlingmaier; Martin Hrabe de Angelis; Felix Beuschlein;
11:30 HTB2 Characterization of human adult stem cell populations isolated from subcutaneous and visceral adipose tissue
Presenter: S. Baglioni (Italy)
 Silvana Baglioni; Michela Francalanci; Roberta Squecco; Adriana Lombardi; Giulia Cantini; Roberta Angeli; Stefania Gelmini; Daniele Guasti; Susanna Benvenuti; Francesco Annunziato; Daniele Bani; Francesco Liotta; Fabio Francini; Giuliano Perigli; Mario Serio; Michaela Luconi;
11:45 HTB3 Functional relevance of MC3R and GHSR heterodimerization in hypothalamic weight regulation
Presenter: A. Rediger (Germany)
 Anne Rediger; Patrick Tarnow; Annette Gruters; Michael Schafer; Rainer Strotmann; Torsten Schoneberg; Heike Biebermann;
12:00 HTB4 Mice deficient for the Sam68 RNA binding protein are protected from dietary obesity and insulin resistance.
Presenter: G. Vogel (Canada)
 Gillian Vogel; Stephane Richard;
12:15 HTB5 Mutations in a novel exon of the LH receptor gene cause male pseudohermaprhoditism
Presenter: J. Gromoll (Germany)
 Joerg Gromoll; Nina Kossack; Annette Richter-Unruh; Manuela Simoni;
13:00 - 14:30 Satellite Symposium: Pfizer - 15 Years of KIMS: Highlighting Unmet Needs in Hypopituitary Patients
Halic Room
13:00 GHD in Adults Becoming a Clinical Entity
F. F. Casanueva (Spain)
13:20 Benefits of GH Replacement in Adults - Why Some Patients Remain Untreated
F. F. Casanueva (Spain) & G. Johannsson (Sweden)
13:40 Other Hormones - Should We Consider Replacements?
A. Brooke (UK)
13:50 Other Hormones - Should We Consider Replacements?
A. Mukherjee (UK)
14:00 Reception Celebrating 15 Years of KIMS
13:00 - 14:30 Satellite Symposium: Bristol-Myers Squibb - Astra Zeneca: Exploring new therapeutic options in Type 2 diabetes: the incretin system and DDP-IV inhibitors
Chairs: L. Van Gaal (Belgium) & H. Ilkova (Turkey)

 Topkapi Rooms A+B
13:00 Rationale for incretin-based therapies in the treatment of Type 2 diabetes
L. Van Gaal (Belgium)
13:30 The place of DPP-IV inhibitors in the landscape of oral glucose lowering treatments
B. Gallwitz (Germany)
14:00 Saxagliptin: clinical profile of a new DPP-IV inhibitor
A. Pfuetzner (Germany)
13:00 - 14:30 Lunch & Exhibition
The President meets with New Members of the ESE
 Lower Foyer of Anadolu Auditorium
13:00 -15:30 Poster session - Talk to Me!
Posters Presented P221 - P440
14:30 - 15:30 Meet the Expert 5
Halic Room
ME5 Thyroid Dysfunction Induced by Amiodarone
W. Wiersinga (The Netherlands)
14:30 - 15:30 Meet the Expert 6
Dolmabahce Rooms A+B+C
ME6 Growth in childhood and adolescence as function of hormonal activity and nutrition
Z. Zadik (Israel)
14:30 - 15:30 Meet the Expert 7
Topkapi Rooms A+B
ME7 Menopausal Hormone Therapy and Cardiovascular Disease: the Women's Health Initiative (WHI) Randomized Placebo-controlled Hormone Trials
M. Stefanick (USA)
14:30 - 15:30 Meet the Expert 8
Marmara Room
ME8 Cushing’s syndrome : pitfalls in diagnosis and management
X. Bertagna (France)
15:30 - 17:00 Symposium 16: Neuroendocrine Tumours
Chairs: W.W. de Herder (The Netherlands) & F.S. Hamulu (Turkey)

 Anadolu Auditorium
15:30 S16.1 Novel approaches in the treatment of NET
K. Oberg (Sweden)
15:50 S16.2 Molecular genetics of Neuroendocrine Tumours
H. Neumann (Germany)
16:10 S16.3 Peptide Receptor Radiotherapy for NET
D. Kwekkeboom (The Netherlands)
16:30 S16.4 PET Based Somatostatin Receptor Imaging of NET
I. Virgolini (Austria)
15:30 - 17:00 Symposium 17: Stem Cell Niches in the Endocrine System
Chairs: C. Alvarez (Spain) & E. Karaoz (Turkey)

 Halic Room
15:30 S17.1 Stem Cell Biology - Lessons to learn from the Fly
L. Gilboa (Israel)
16:00 S17.2 A population of progenitor/stem cells in the adult pituitary.
K. Rizzoti (UK)
16:30 S17.3 Thyroid – stem cells: normal development and tumorigenesis
M. Derwahl (Germany)
15:30 - 17:00 Oral Communication 4: Acromegaly/IGF1/Type 2 Diabetes
Chairs: A. Lewinski (Poland) & C. Dieguez (Spain)

 Marmara Room
15:30 OC4.1 High-dose octreotide LAR in patients with acromegaly inadequately controlled by conventional somatostatin analogue therapy: a randomized, controlled trial
Presenter: A. Giustina (Italy)
 Andrea Giustina; Stefania Bonadonna; Giovanna Bugari; Annamaria Colao; Renato Cozzi; Salvatore Cannavo; Laura De Marinis; Ettore degli Uberti; Fausto Bogazzi; Gherardo Mazziotti; Francesco Minuto; Marcella Montini; Ezio Ghigo;
15:45 OC4.2 Both insulin resistance and insulin secretion are involved in the pre-diabetes of acromegaly
Presenter: D. Niculescu (Romania)
 Dan Niculescu; Mariana Purice; Radu Lichiardopol; Mihail Coculescu;
16:00 OC4.3 Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin (SST), growth hormone (GH)-releasing hormone (GHRH) and ghrelin in a non-human primate (Papio anubis).
Presenter: R. M. Luque (Spain)
 Jose Cordoba Chacon; Justo P. Castano; Rhonda D. Kineman; Raul M Luque;
16:15 OC4.4 Development of a novel anti - IGF1 receptor immunoliposomal cancer therapy with enhanced therapeutic efficiency
Presenter: C. Hantel (Germany)
 Constanze Hantel; Felicitas Lewrick; Sebastian Schneider; Oliver Zwermann; Martin Reincke; Regine Peschka-Suss; Felix Beuschlein;
16:30 OC4.5 Regulation of Obestatin Levels During Unacylated Ghrelin Infusions in Normal and Type 2 Diabetic Patients
Presenter: D. H. St-Pierre (Italy)
 David H. St-Pierre; Fabio Settanni; Ilaria Olivetti; Elena Gramaglia; Andrea Benso; Fabrizio Riganti; Ezio Ghigo; Fabio Broglio;
16:45 OC4.6 Cardiovascular effects of chronic sildenafil treatment in men with Type 2 diabetes
Presenter: A. Isidori (Italy)
 Andrea Isidori; Elisa Giannetta; Iacopo Carbone; Dario Vizza; Susanna Orano; Enzo Vingolo; Vincenzo Bonifacio; Andrea Lenzi;
15:30 - 17:00 Highlight Session 2: Clinical
Chairs: J. Wass (UK) & S. Webb (Spain)

 Topkapi Rooms A+B
15:30 HTC1 Reduction in incidence of Type 2 diabetes by lifestyle modification in a Middle Eastern urban population: Tehran Lipid and Glucose Study
Presenter: H. Harati (Islamic Republic of Iran)
 Hadi Harati; Farzad Hadaegh; Laleh Ghanei; Fereidoun Azizi;
15:45 HTC2 Primary Hyperparathyroidism (Nationwide Cohort Study): An increased risk of cancer and decreased survival
Presenter: S. Ghosh (UK)
 Sujoy Ghosh; Andrew Collier; David Clark; Tarik Elhadd; Iqbal Malik;
16:00 HTC3 Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival
Presenter: G. Assie (France)
 Guillaume Assie; Aurélien de Reynies; David Rickman; Frédérique Tissier; Lionel Groussin; Fernande Rene-Corail; Bertrand Dousset; Xavier Bertagna; Eric Clauser; Jérôme Bertherat;
16:15 HTC4 Functional anayses of 4 novel RET germline mutations: Juxtamembrane mutations display the highest level of Autophosphorylation
Presenter: D. Cordella (Italy)
 Daniela Cordella; Marina Muzza; Johny Bombled; Brigitte Bressac-de Paillerets; Paolo Beck-Peccoz; Martin Schlumberger; Luca Persani; Laura Fugazzola;
16:30 HTC5 Quality of Life in Acromegalic Patients during long-term Somatostatin Analog Treatment with and without Pegvisomant
Presenter: Sebastian Neggers (The Netherlands)
 Sebastian Neggers; Wouter Herder; Richard Feelders; Xavier Badia; Susan Webb; Aart-Jan Lely;
17:00 - 17:15 Coffee Break & Exhibition
17:15 - 18:00 Plenary Lecture 4
Chair: L. Groop (Sweden)
 Anadolu Auditorium
PL4 New Insight in the Genetics of Type 2 Diabetes and Obesity from Genome Wide Associations Studies
P. Froguel (France)
18:15 - 19:30 Annual General Meeting of the European Society of Endocrinology (ESE)
Anadolu Auditorium

Tuesday 28 April 2009
08:00-20:00 Registration
08:30 - 10:00 Symposium 18: Should Adrenal Venous Sampling be performed Before Adrenalectomy in Primary Aldosteronism? (Pro-Con)
Chair: B. Allolio (Germany)
 Halic Room
S18.1 PRO: Adrenal venous sampling should be performed before adrenalectomy in primary aldosteronism?
P. Mulatero (Italy)
S18.2 CON: Should adrenal venous sampling be performed before adrenalectomy in primary aldosteronism? Con
L. Amar (France)
08:30 - 10:00 Symposium 19: Bone Endocrinology
Chairs: A. Giustina (Italy) & R. Tanakol (Turkey)

 Topkapi Rooms A+B
08:30 S19.1 Endocrine regulation of energy metabolism by the skeleton
P. Ducy (USA)
08:50 S19.2 Neuronal Regulation of Bone Remodeling
F. Elefteriou (USA)
09:10 S19.3 Role of Oxidative Stress in Skeletal Involution
S. Manolagas (USA)
09:30 S19.4 Lipoprotein Involvement in Bone Metabolism
B. Obermayer-Pietsch (Austria)
08:30 - 10:00 Young Active Research Symposium - Mechanisms in Adrenal Disease - from insufficiency to hyperfunction
Chair: S. Hahner
 This symposium is an unrestricted eductional grant from Merck-Serono
 Marmara Room
08:30 Mechanisms of disease in familiar glucocorticoid deficiency
L. Metherell (UK)
08:50 TASK potassium channels and their role in adrenal gland zonation and mineralocorticoid homeostasis
D. Heitzmann (Germany)
09:10 News and views in the molecular pathogenesis of adrenocortical tumours
R. Libe (France - Italy)
09:30 Hexose-6-phosphate dehydrogenase: Linking glucocorticoid and glucose metabolism and endoplasmic reticulum
G. Lavery (UK)
10:05 - 10:50 Plenary Lecture 5
Chair: B. Glaser (Israel)
 Anadolu Auditorium
PL5 New Therapies for Diabetes - Genetically Engineering Tissues to maintain Glucose Homeostasis
F. Bosch (Spain)
10:05 -11:15 Coffee Break & Exhibition
11:15 - 12:45 Symposium 20 - Thyroid Cancer
Chairs: M. Alevizaki (Greece) & B. Jarzab (Poland)

 Anadolu Auditorium
11:15 S20.1 C Cell Neoplasia
R. Elisei (Italy)
11:35 S20.2 Ultrasound Diagnosis and Follow-up of thyroid Cancer
M. Erdogan (Turkey)
11:55 S20.3 Advances in management of thyroid cancer with novel chemotherapy agents
C. Nutting (UK)
12:15 S20.4 Pregnancy after exposure to radioiodine
S. Hyer (UK)
11:15 - 12:45 Symposium 21 - Current problems in the Management of Pitutary Tumours
Chairs: E. M. Erfurth (Sweden) & T. Erbas (Turkey)

 Halic Room
11:15 S21.1 Cardiovascular Morbidity and Mortality in Patients Treated for Craniopharyngioma
A. Pereira (The Netherlands)
11:35 S21.2 Factors Associated with Hypothalamic Morbidity in Patients with Craniopharyngiomas
H. Holmer (Sweden)
11:55 S21.3 Treatment and prognosis of Non-Functioning Pituitary Adenomas
A. Colao (Italy)
12:15 S21.4 Treatment Options for Aggressive Pituitary Tumors
A. Grossman (UK)
11:15 - 12:45 Symposium 22 - Tumorigenesis in Pheochromocytoma / Paragangliomas
Chairs: F. Plouin (France) & S. Damjanovic (Serbia)

 Topkapi Rooms A+B
11:15 S22.1 The Warburg Effect in Pheochromocytoma: A Link Between Genetic Disorders and Cell Metabolism
J. Favier (France)
11:35 S22.2 Hypoxia-Induced Angiogenesis in Pheochromocytoma
E. Maher (UK)
11:55 S22.3 Antiangiogenic Medication in Malignant Pheochromocytoma
M. Azizi (France)
12:15 S22.4 Clinical, biochemical and genetic aspects of malignant pheochromocytoma
M. Mannelli (Italy)
11:15 - 12:45 Oral Communication 5 - Thyroid Basic & Clinical
Chairs: J. Medina (Portugal) & P. Beck-Peccoz (Italy)

 Marmara Room
11:15 OC5.1 Neurological and behavioral phenotypes in mice lacking Mct8-mediated neuronal T3 uptake
Presenter: U. Schweizer (Germany)
 Ulrich Schweizer; Eva Wirth; Stephan Roth; Josef Kohrle; Annette Gruters;
11:30 OC5.2 Selenium and iodine determination from single murine thyroid lobes by TXRF-spectroscopy
Presenter: K. Renko (Germany)
 Kostja Renko; Thomas Behrends; Hagen Stosnach; Josef Kohrle; Lutz Schomburg;
11:45 OC5.3 The role of N-linked oligosaccharides on the function of thyrotropin: development of new agonists and antagonists
Presenter: F. Fares (Israel)
 Fuad Fares; Naiel Azzam; Rinat Bar-Shalom; Zaki Kraiem;
12:00 OC5.5 Selenium supplementation fails to improve thyroid hormone metabolism in subjects with SBP2 gene mutations
Presenter: L. Schomburg (Germany)
 Lutz Schomburg; Alexandra M. Dumitrescu; Xiao-Hui Liao; Bassam Bin-Abbas; Johanna Hoeflich; Josef Kohrle; Samuel Refetoff;
12:15 OC5.6 Graves patients with high sCTLA-4 level are at risk of severe ophthalmopathy
Presenter: J. Daroszewski (Poland)
 Jacek Daroszewski; Edyta Pawlak; Lidia Karabon; Marek Bolanowski; Anna Jonkisz; Irena Frydecka;
13:00 - 14:30 Satellite Symposium: Merck Serono - Adult Growth Hormone Deficiency: from diagnosis to management
Chair: G. Aimaretti (Italy)
 Halic Room
13:00 What is the best diagnostic test for adult GHD?
A. Colao (Italy)
13:30 GHD after Traumatic Brain injuries: mechanism and management
F. Kelestimur (Turkey)
14:00 The effects of GH therapy on thyroid function
A. Agha (Ireland)
13:00 - 14:30 Satellite Symposium: Otsuka - Hyponatraemia: Symptoms and Treatment Options
Chair: B. Allolio
 Topkapi Rooms A+B
13:00 Welcome and Introduction
B. Allolio
13:05 Prevalence, clinical characteristics and consequences of hyponatraemmia
C. Thompson
13:30 Review of current practice and guidelines for the treatment of hyponatremia
M. Mannelli
13:55 Future directions for the treatment of hyponatraemia
J. Verbalis
14:20 Questions and Answers
13:00 - 14:30 Lunch & Exhibition
13:00 - 15:30 Poster session - Talk to Me!
Posters Presented P441 - P688
14:30 - 15:30 Meet the Expert 9
Halic Room
ME9 New Drugs in the Management of Obese Patients
F. Casanueva (Spain)
14:30 - 15:30 Meet the Expert 10
Topkapi Rooms A+B
ME10 Nonclassical Congenital Adrenal Hyperplasia (CAH)
C. Dacou-Voutetakis (Greece)
14:30 - 15:30 Meet the Expert 11
Dolmabahce Rooms A+B+C
ME11 The value of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D measurements
P. Lips (The Netherlands)
14:30 - 15:30 Meet the Expert 12
Marmara Room
ME12 Primary Aldosteronism
J. Connell (UK)
15:30 - 17:00 Symposium 23: Adrenocortical Tumours: Pathogenesis and Management
Chairs: S. Tsagarakis (Greece) & A. Gurlek (Turkey)

 Anadolu Auditorium
15:30 S23.1 Molecular pathogenesis of adrenocortical tumors
F. Beuschlein (Germany)
15:50 S23.2 Aberrant receptors (AR) in adrenal Cushing’s syndrome
J. Bertherat (France)
16:10 S23.3 Prognostic factors and adjuvant mitotane therapy for ACC
M. Terzolo (Italy)
16:30 S23.4 Chemotherapy and radiotherapy for adrenocortical carcinoma
M. Fassnacht (Germany)
15:30 - 17:00 Symposium 24: Enviromental Pollutants as Endocrine Disruptors
Chairs: N. Skakkebaek (Denmark) & A. Juul (Denmark)

 Halic Room
15:30 S24.1 Environmental Chemical and Thyroid Signalling
H. Dong (Canada)
15:50 S24.2 Molecular Mechanisms of AhR and NR crosstalk.
I. Pongratz (Sweden)
16:10 S24.3 Endocrine Disruptors or Goitrogens? Effects of UV Screens, Synthetic and Nutritive Compounds on Thyroid Function
J. Köhrle (Germany)
16:30 S24.4 Amphibians as Sensors of Endocrine Disruptors
W. Kloas (Germany)
15:30 - 17:00 Symposium 25: Pathophysiology and treatment of Type 2 Diabetes
Chairs: P. Froguel (France) & N. Baskal (Turkey)

 Topkapi Rooms A+B
15:30 S25.1 Genetics of Type 2 Diabetes
L. Groop (Sweden)
15:50 S25.2 Monogenic Obesity
S. Farooqi (UK)
16:10 S25.3 FTO and obesity
C. Dina (France)
16:30 S25.4 Incretin-based Therapies
S. Madsbad (Denmark)
15:30 - 17:00 Oral Communication 6: Pediatric Endocrinology / Bone
Chairs: A. Nilsson (Sweden) & S. Lightman (UK)

 Marmara Room
15:30 OC6.1 Pseudohypoparathyroidism type Ia and GNAS epigenetic defects: clinical evaluation and molecular analysis in 40 patients with Albright’s hereditary osteodystrophy
Presenter: G. Mantovani (Italy)
 Giovanna Mantovani; Luisa de Sanctis; Annamaria Barbieri; Pamela Labarile; Erika Peverelli; Andrea G Lania; Paolo Beck-Peccoz; Anna Spada;
15:45 OC6.2 Recent Decline in Age at Breast Development and Prolongation of Puberty Duration in Girls
Presenter: L. Aksglaede (Denmark)
 Lise Aksglaede; Kaspar Sorensen; Jorgen H Petersen; Niels E Skakkebaek; Anders Juul;
16:00 OC6.3 Ghrelin and obestatin levels in normal weighted and obese prepubertal children.
Presenter: F. Prodam (Italy)
 Flavia Prodam; Simonetta Bellone; Letizia Trovato; Erica Grassino; Stefania Moia; Irene De Marchi; Francesca De Rienzo; Gianni Bona;
16:15 OC6.4 Appearance matters: the impact of perceived altered appearance as a result of Klinefelter’s Syndrome on psycho-social functioning
Presenter: S. Jackson (UK)
 Sue Jackson; Marianne Morris;
16:30 OC6.5 Corticol bone size is associated with serum sex hormone-binding globulin levels in healthy men at the age of peak bone mass.
Presenter: G. Vanbillemont (Belgium)
 Griet Vanbillemont; Bruno Lapauw; Youri Taes; Veerle Bogaert; Stefan Goemaere; Hans-Georg Zmierczak; Dirk De Bacquer; Jean-Marc Kaufman;
16:45 OC6.6 Reduced Selenoprotein P expression affects bone formation
Presenter: A. Hog (Germany)
 Antonia Hog; Kostja Renko; Petra Seemann; Uwe Kornak; Lutz Schomburg;
17:00 - 17:15 Coffee Break & Exhibition
17:15 - 17:30 Young Investigator Awards
Anadolu Auditorium
17:30 - 18:15 Plenary Lecture 6
Chair: P. Beck-Peccoz (Italy)
 Anadolu Auditorium
PL6 Thyroid Hormone Transporters: From Gene to Disease
H. Krude (Germany)
20:30- ECE Bazaar Party

Wednesday 29April 2009
08:00-13:00 Registration
08:30 - 10:00 Symposium 26: Thyroid, Pregnancy and Fertility
Chairs: W. Wiersinga (The Netherlands) & M. Erdogan (Turkey)

 Halic Room
08:30 S26.1 Thyroid disorders, Infertility and Miscarriages
L. Chiovato (Italy)
08:50 S26.2 Thyroid dysfunction during pregnancy
M. Karbownik-Lewinska (Poland)
09:10 S26.3 Postpartum Thyroiditis
R. Negro (Italy)
09:30 S26.4 Consensus Guidelines for the Management of Thyroid Disorders Associated with Pregnancy: An Overview
D. Glinoer (Belgium)
08:30 - 10:00 Symposium 27: Impact of SNPs on Hormone Function
Chairs: I. Huhtaniemi (UK) & D. Gogas Yavuz (Turkey)

 Marmara Room
08:30 S27.1 Pitfalls and chances of association studies
B. Muller-Myhsok (Germany)
08:50 S27.2 Impact of SNP on hormone function: FSH receptor
M. Simoni (Italy)
09:10 S27.3 Estrogen and Androgen Receptor Variants
A. Giwercman (Sweden)
09:30 S27.4 LH receptor variance
D. Piersma (The Netherlands)
08:30 - 10:00 Symposium 28: Receptor Modulators
Chairs: J. Orly (Israel) & S. Yarman (Turkey)

Topkapi Rooms A+B
08:30 S28.1 Diverse actions of the Nuclear Receptor Corepressor RIP140 in Metabolic Regulation
M. Christian (UK)
08:50 S28.2 Glucocorticoid Receptor Ligands, dissociating between Transrepression and Transactivation.
G. Haegeman (Belgium)
09:10 S28.3 Selective Androgen Receptor Modulators: Mechanisms and Therapeutic Potential
S. Bhasin (USA)
09:30 S28.4 Thyroid Hormone Signaling During Brain Development: Genetic Dissection in Mouse
F. Flamant (France)
08:30 - 10:00 Debate - What to do next when metformin does not work in Type 2 Diabetes?
Chair: G. Bolli (Italy)
 Anadolu Auditorium
08:30 D1.1 Add SU
V. Pirags (Lithuania)
09:00 D1.2 Add Insulin
T. Battelino (Slovenia)
09:30 D1.3 Add Incretin
B. Gallwitz (Germany)
10:05 - 10:50 Plenary Lecture 7
Chair: E. Ghigo (Italy)
 Anadolu Auditorium
PL7 Implications of adrenal hormone pulsatility
S. Lightman (UK)
10:50 - 11:15 Coffee Break & Exhibition
11:15 - 12:15 Meet the Expert 13
Dolmabahce Rooms A+B+C
ME13 New Pharmaceutical Contraceptive Approaches
P. Bouchard (France)
11:15 - 12:15 Meet the Expert 14
Halic Room
ME14 Molecular Biology for Clinicians
J. Kopchick (USA)
11:15 - 12:15 Meet the Expert 15
Topkapi Rooms A+B
ME15 Diagnosis and Treatment of Type 2 Diabetes Mellitus in Childhood
N. Gungor (Turkey)
11:15 - 12:15 Meet the Expert 16
Marmara Room
ME16 Bariatric Surgery: A Cure for Diabetes?
G. Dakin (USA)
12:15 - 13:00 Plenary Lecture 8
Chair: E. Nieschlag (Germany)
 Anadolu Auditorium
PL8 11beta-hydroxysteroid dehydrogenases: Common lessons from rare mutations
P. Stewart (UK)
13:00-13:10 Farewell and Invitation to Prague
Anadolu Auditorium